Triethylamine → HCID 68141868, compound

Participants

Reaction Steps

A solution of 3β-chloro-3α-methyl-7β-phenoxyacetamidocepham-4α-carboxylic acid (2.74 g), p-nitrobenzyl bromide (1.52 g), and triethylamine (1 ml) in dimethylformamide (30 ml) is kept at room temperature for 3 hours. The reaction mixture is poured into ice water, and extracted with ethyl acetate. The extract solution is washed with water, dried, and evaporated in vacuo to give p-nitrobenzyl 3β-chloro-3α-methyl-7β-phenoxyacetamidocepham-4α-carboxylate (3.45 g). Yield: 93%.

Provenance & Evidence