HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzamide, 2-(hydroxyphenylmethyl)-N-methyl- → 3-Phenylphthalide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzamide, 2-(hydroxyphenylmethyl)-N-methyl- | HCID 12241019 | — |
| Solvent | 1,2-Dichlorobenzene | HCID 7239 | — |
| Product | 3-Phenylphthalide | HCID 95365 | — |
Reaction Steps
A mixture of 76.5 g. of α-hydroxy-N-methyl-α-phenyl-o-toluamide and (0.314 mole) 150 ml. o-dichlorobenzene is heated at reflux for 18 hours. The mixture is cooled and filtered and the resulting solid triturated with cold ether to give 3-phenyl phthalide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03989704 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-0b025cfac60f45e2a0bdce5e65d4e363 |
| Source note | uspto-grants-1976_11 |