Cinnamoylbenzene → HCID 12391101, compound

HRID 1729687Notes

Reaction equation

HRID 1729687 reaction equation
[CH:1](=[CH:8][C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:17]([O:19][C:20](=[O:25])[CH2:21][C:22](=[NH:24])[NH2:23])[CH3:18]>C(O)C>[CH2:17]([O:19][C:20]([C:21]1[CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:8]=[C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[NH:23][C:22]=1[NH2:24])=[O:25])[CH3:18]

Participants

4

Reactant 2

HCID 7189CinnamoylbenzeneHCID 4599837Carbamimidoyl-acetic acid ethyl ester

Product 1

HCID 12391101HCID 12391101, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Upon heating a solution of 20.8 of benzylideneacetophenone and 13.0 g of amidinoacetic acid ethyl ester in 250 ml of ethanol for 2 hours, 2-amino-4,6-diphenyl-1,4-dihydropyridine-3-carboxylic acid ethyl ester of melting point 159°C (ethanol) is obtained. Yield: 69 percent of theory.

Sources & evidence

ORD record
ord-59f8cbdef4a2490db6e0c5a3ecd919a1
Source dataset
uspto-grants-1976_11
Patent number
US03989708

Reaction notes

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