HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 2-Amino-6-methyl-4-(3-chlorophenyl)-1,4-dihydropyridine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 3-Chlorobenzylideneacetone | HCID 141576 | — |
| Reactant | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-6-methyl-4-(3-chlorophenyl)-1,4-dihydropyridine-3-carboxylic acid ethyl ester | HCID 12391098 | 56% |
Reaction Steps
After heating a solution of 18.1 g of 3-chlorobenzylideneacetone and 13.0 g of amidinoacetic acid ethyl ester in 150 ml of ethanol for 3 hours, 2-amino-6-methyl-4-(3-chlorophenyl)-1,4-dihydropyridine-3-carboxylic acid ethyl ester of melting point 140°C (isopropanol) is obtained. Yield: 56 percent of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03989708 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-6e3af589c7304c3f9b0ebdbd8f479363 |
| Source note | uspto-grants-1976_11 |