Chloroacetone → HCID 12257245, compound

Participants

Reaction Steps

To a solution of 12.6 g. of the product of Example 1 and 8.1 g. of potassium t-butoxide in 100 ml. of dimethyl sulfoxide was added, dropwise with stirring, 15 ml. of chloroacetone. The mixture was treated and the product was recovered as shown in Example 2, except that the product was crystallized from ethanol-water. The product was 10.7 g. of 3-(acetlymethoxy)benzo[b]thiophene-2-carboxylic acid, methyl ester, m.p. 57°-58°C. It was identified by NMR analysis and elemental microanalysis as follows.

Provenance & Evidence