Triethylamine → N-[(Dodecanoyloxy)methyl]-N,N-diethylethanaminium chloride

Participants

Reaction Steps

2.49 g (0.01 mol) chloromethyl n-dodecanoate (1b) and 1.01 g (0.01 mol) triethylamine were mixed and heated together at 90° for 3 hr. On cooling to room temperature, anhydrous ether was added to the mixture and the mixture was triturated in anhydrous ether overnite. The solid was isolated by filtration under a nitrogen atmosphere and thoroughly washed with ether. After drying in vacuo over calcium sulfate at room temperature 0.6 g (0.002 mol), 20%, 2h was obtained as a hygroscopic solid, mp 72°-77°.

Provenance & Evidence