Ammonium Chloride → Hydrochloric Acid

Participants

Reaction Steps

7.4 g (0.0255 mol) of 6,7-dihydro-2-methyl-1-(2-methylaminoethyl)-indolo[1,7-ab][1]benzazepine were dissolved in 74 ml of tetrahydrofuran (freshly distilled from sodium) and 148 ml of liquid ammonia and reduced with 1.17 g (2 × 0.0255 mol) of sodium. Addition of a further 0.12 g (10% excess) of sodium caused formation of a permanent blue colour. After decomposition with 3 g of ammonium chloride, the mixture was worked up in the manner described in part B of Example 2. The basic product was distilled at ca 150° C (air-bath temperature)/10-5 mm Hg to give the trans-1,2,6,7-tetrahydro-2-methyl-1-(2-methylaminoethyl)-indolo[1,7-ab][1]benzazepine whose hydrochloride melted at 198°-200° C.

Provenance & Evidence