Carbon Dioxide → HCID 54019971, compound

Participants

Reaction Steps

0.5 Mole of N-methylpiperazine are added to 0.5 mole of cyanoacetic acid in 150 cc. of dioxan at a temperature kept at around 0° C. This is followed by the addition of 1 mole of formaldehyde in the form of a 30% aqueous solution. After the heat effect has abated, the mixture is stirred until there is no further evolution of carbon dioxide gas (approximately 2 hours). 200 cc. of water are then added, the product extracted with ether, dried over sodium sulphate and the ether removed in vacuo, followed by distillation.

Provenance & Evidence