4-Methylthiazole → 1-(4-Methyl-1,3-thiazol-2-yl)propan-1-one

HRID 1729733Notes

Reaction equation

[CH3:1][C:2]1[N:3]=[CH:4][S:5][CH:6]=1.C([Mg]Br)C.[C:11](Cl)(=[O:14])[CH2:12][CH3:13]>>[CH3:1][C:2]1[N:3]=[C:4]([C:11](=[O:14])[CH2:12][CH3:13])[S:5][CH:6]=1

Participants

Reactant 3

HCID 127484-Methylthiazole

HCID 62324Propionyl chloride

HCID 178418443HCID 178418443, compound

Product 1

HCID 205603521-(4-Methyl-1,3-thiazol-2-yl)propan-1-one

Procedure

b. 4-Methyl-2-propionyl-thiazole was prepared according to the method described in Bull. 20, 702 (1953) by reacting 4-methyl-thiazole with ethyl-magnesium bromide and acylating the obtained Grignard intermediate with propionyl chloride. The product has a b.p. of 83°-88° C./9 mm. Hg.

Sources & evidence

ORD record: ord-f7a44aea31f34c0796ccef877effe38e
Source dataset: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03989713

Reaction notes

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