反应详情

A solution of 5-amino-4-benzoyl-3-n-butoxybenzoic acid (1.0 g) and formic acid (10 ml) is stirred at room temperature for 24 hours. After cooling, the resulting precipitate is collected and washed with ice-cold formic acid followed by cold water. After drying and recrystallization from ethanol, 4-benzoyl-3-n-butoxy-5-formamidobenzoic acid is obtained with a melting point of 180°-183° C.

1. temperatureAfter cooling
2. customthe resulting precipitate is collected
3. washwashed with ice-cold formic acid
4. customAfter drying
5. customrecrystallization from ethanol