反应详情

A mixture of 5-amino-4-benzoyl-3-n-butoxybenzoic acid (0.8 g), acetic anhydride (0.8 ml) and acetic acid (8.0 ml) is heated on a steam-bath for 1 hour. After cooling, the resulting solution is poured into water (about 20 ml) and the mixture is left at room temperature for about 20 hours. The resulting precipitate is collected by filtration and washed with water. After drying and recrystallization twice from aqueous ethanol, 5-acetamido-4-benzoyl-3-n-butoxybenzoic acid is obtained with a melting point of 177°-178° C.

1. temperatureis heated on a steam-bath for 1 hour
2. temperatureAfter cooling
3. filtrationThe resulting precipitate is collected by filtration
4. washwashed with water
5. customAfter drying
6. customrecrystallization twice from aqueous ethanol