Dimethylamine → HCID 12409664, compound

Participants

Reaction Steps

A mixture of 4-benzoyl-3-benzyloxy-5-chloroacetamidobenzoic acid (0.85 g) and 20% w/w aqueous dimethylamine (10 ml) is left at room temperature for 20 hours and is then evaporated in vacuo. The residue is triturated with conc. hydrochloric acid (about 5 ml) and the resulting precipitate is collected by filtration and dried. After recrystallization from methyl cellosolve, 4-benzoyl-3-benzyloxy-5-dimethylaminoacetamidobenzoic acid hydrochloride is obtained with a melting point of 264.5°-265.5° C.

Provenance & Evidence