Chloroform → HCID 86734138, compound

Participants

Reaction Steps

To a stirred solution of 150 parts of ethyl N-[2-(ethoxycarbonyl)ethyl]-β-alanine hydrochloride in 1800 parts of trichloromethane are added 150 parts of N,N-diethylethanamine, while cooling. Then there are added dropwise 68 parts of methyl chloroformate. Upon completion, stirring is continued overnight at room temperature. The formed precipitate is filtered off and the filter-cake is washed with methylbenzene. The filtrate is evaporated and water is added to the residue. The product is extracted with methylbenzene. The extract is washed three times with water, dried, filtered and evaporated. The residue is distilled, yielding ethyl N-[2-(ethoxycarbonyl)ethyl]-N-(methoxycarbonyl)-β-alanine; bp. 137°-140° C at 0.2 mm. pressure.

Provenance & Evidence