Potassium Iodide → HCID 21500266, compound

Participants

Reaction Steps

A mixture of 7.6 parts of 1-chloro-4,4-bis(4-fluorophenyl)butane, 4.6 parts of 1,3-dihydro-5-methyl-1-(4-piperidinyl)-2H-benzimidazol-2-one, 10 parts of sodium carbonate, 0.1 parts of potassium iodide and 80 parts of 4-methyl-2-pentanone is stirred and refluxed overnight. The reaction mixture is cooled and poured onto water, whereupon the product is precipitated. It is filtered off, boiled in 2-propanol and treated with activated charcoal. The latter is filtered off and the product is allowed to crystallize from the filtrate, yielding 1-{1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl}-1,3-dihydro-5-methyl-2H-benzimidazol-2-one 2-propanolate; mp. 190 ° C.

Provenance & Evidence