Methyl Isobutyl Ketone → HCID 21500290, compound

Participants

Reaction Steps

A mixture of 3.5 parts of 1-chloro-4,4-bis(4-fluorophenyl)-butane, 2.5 parts of 6-chloro-1,3-dihydro-1-(4-piperidinyl)-5-(trifluoromethyl)-2H-benzimidazol-2-one, 2.65 parts of sodium carbonate and 100 parts of 4-methyl- 2-pentanone is stirred and refluxed overnight with water-separator. The reaction mixture is cooled to room temperature and water is added. The organic layer is separated, dried, filtered and evaporated. The solid residue is purified by column-chromatography over silicagel, using a mixture of trichloromethane and 5% of methanol as eluent. The pure fractions are collected and the eluent is evaporated. The residue is crystallized from 2-propanol, yielding 6-chloro-1-{1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl}-1,3-dihydro-5-(trifluoromethyl)-2H-benzimidazol-2-one 2-propanolate; mp. 200° C.

Provenance & Evidence