反应详情

A mixture of 7.35 parts of 1-chloro-4,4-diphenylbutane, 6.3 parts of 5-chloro-1-(4-piperidyl)-2-benzimidazolinone, 6.35 parts of sodium carbonate, 0.1 parts of potassium iodide and 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 48 hours with water-separator. The reaction mixture is cooled to room temperature and water is added. The organic layer is separated, dried, filtered and evaporated. The residue is crystallized twice; first from 2-propanol and then from 4-methyl-2-pentanone, yielding 5-chloro-1,3-dihydro-1-[1-(4,4-diphenylbutyl)-4-piperidinyl]-2-H-benzimidazol-2-one; mp. 164.7° C.

1. customThe organic layer is separated
2. customdried
3. filtrationfiltered
4. customevaporated
5. customThe residue is crystallized twice