Potassium Iodide → HCID 21500286, compound

Participants

Reaction Steps

A mixture of 7.85 parts of 1-chloro-4-(4-fluorophenyl)-4-phenylbutane, 6.3 parts of 5-chloro-1-(4-piperidyl)-2-benzimidazolinone, 6.35 parts of sodium carbonate, 0.1 parts of potassium iodide and 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 48 hours with water-separator. The reaction mixture is cooled to room temperature and water is added. The organic layer is separated, dried, filtered and evaporated. The residue is crystallized from 4-methyl-2-pentanone, yielding 5-chloro-1-{1-[4-(4-fluorophenyl)-4-phenyl-butyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one; mp. 182.9° C.

Provenance & Evidence