反应详情

A solution of 5.12 g. (0.020 mole) of 3'-bromoacetylacetanilide in 70 ml. of acetone is added to a stirred solution of 2.04 g. (0.020 mole) of 2-amino-2-thiazoline in 30 ml. of acetone. The mixture is stirred 1.5 hours and the precipitate then filtered, washed with acetone and dried to give 6.00 g. of white solid, which on recrystallization from water gives the product, melting point 275°-277°C. Anal. Calcd. for C13H16BrN3O2S: C, 43.58; H, 4.50; Br, 22.31; N, 11.73; S, 8.95. Found: C, 43.99; H, 4.66; Br, 22.51; N, 11.72; S, 9.14.

1. filtrationthe precipitate then filtered
2. washwashed with acetone
3. customdried
4. customto give 6.00 g
5. customof white solid, which on recrystallization from water
6. customgives the product, melting point 275°-277°C