HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → N-(2,6-dichlorobenzoyl)-N-(methoxymethyl)-N'-(4-chlorophenyl)-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Chloromethyl Methyl Ether | HCID 7864 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2,6-dichloro-N-(((4-chlorophenyl)amino)carbonyl)benzamide | HCID 92300 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(2,6-dichlorobenzoyl)-N-(methoxymethyl)-N'-(4-chlorophenyl)-urea | HCID 19006383 | — |
Reaction Steps
10.3 g of N-(2,6-dichlorobenzoyl)-N'-(4-chlorophenyl)-urea and 1.88 g of powdered potassium hydroxide (90%) are dissolved 40 ml of dimethyl formamide, after which 4.7 g of methyl iodide are added drop by drop to the clear solution. The resulting reaction is exothermic. After stirring for two hours the solution is diluted with ice water and the solid substance is isolated. Yield 10.3 g. Melting point 124°-126° C. In a completely similar manner but using methoxymethylchloride instead of methyliodide, N-(2,6-dichlorobenzoyl)-N-(methoxymethyl)-N'-(4-chlorophenyl)-urea is produced. Melting point 121.5°-122.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03989842 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-7f2a400ae77844c88c0dc246619dfef9 |
| Source note | uspto-grants-1976_11 |