反应详情

A solution of α-methyl-α-hydroxyfluorene-2-acetic acid (5.7 g) and sulfuric acid (11.4 ml) in dioxane (300 ml) is refluxed for 2 hours. The reaction mixture is poured into ice water and extracted with ether. The ether extracts are washed with water, dried (MgSO4), and evaporated to give the title compound (5.2 g, mp 183°-185°). The analytical sample is prepared by recrystallization from 95% ethanol, mp 190°-191°, λKBr 880 cm-1.

1. extractionextracted with ether
2. washThe ether extracts are washed with water
3. dry with materialdried (MgSO4)
4. customevaporated