HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → (+-)-Cicloprofen
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 21406512 | HCID 21406512 | — |
| Product | (+-)-Cicloprofen | HCID 37589 | — |
Reaction Steps
2.1g. of α-methylfluorene-2-acetonitrile is refluxed in 60% aqueous ethanol (50ml.) containing potassium hydroxide (5g.) until the evolution of ammonia ceases. The ethanol is evaporated and the aqueous solution acidified to pH 2.0 with HCl and extracted with ether. The ether extracts are washed with water, dried (MgSO4) and evaporated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03989841 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-78f597590cd04d3da500a442173e15af |
| Source note | uspto-grants-1976_11 |