Methyl 7-iodo-2,2-dimethylheptanoate → 7-[1-(4(R)-hydroxy-2-nonynyl)ureido]heptanoic acid

Participants

Reaction Steps

The synthesis of this compound is carried out as described in Example 7 except that, in Step A, the ethyl 7-bromo-2-methylheptanoate is replaced by an equimolar amount of methyl 2,2-dimethyl-7-iodoheptanoate. The product of Step A is thus methyl 7-[N-(4-acetoxynonyl)cyanamido]-2,2-dimethylheptanoate. The subsequent steps yield 7-[N-(4-hydroxynonyl)cyanamido]-2,2-dimethylheptanoic acid (B) and 7-[1-(4-hydroxynonyl)ureido]-2,2-dimethylheptanoic acid (C).

Provenance & Evidence