1-Chloro-4-acetoxynonane → 7-[1-(4(R)-hydroxy-2-nonynyl)ureido]heptanoic acid

Participants

Reaction Steps

The synthesis of this compound is carried out as described in Example 1 except that, in Step A, the 1-chloro-4-acetoxynonane is replaced by an equimolar amount of 1-chloro-4-acetoxy-9,9,9trifluorononane (Example E). The product of Step A is thus ethyl 7-[N-(4-acetoxy-9,9,9-trifluorononyl)cyanamido]heptanoate. The subsequent steps yield 7-[N-(4-hydroxy-9,9,9-trifluorononyl)cyanamido]heptanoic acid (B) and 7-[1-(4-hydroxy-9,9,9-trifluorononyl)-ureido]heptanoic acid (C).

Provenance & Evidence