1-Chloro-4-acetoxynonane → 7-[1-(4(R)-hydroxy-2-nonynyl)ureido]heptanoic acid

Participants

Reaction Steps

The synthesis of this compound is carried out as described in Example 1 except that, in Step A, the 1-chloro-4-acetoxynonane is replaced by a equimolar amount of -1-acetoxy-1-(3-bromo-1-propynyl)cyclooctane (Example Q). The product of Step A is thus ethyl 7-{N-[3-(1-acetoxycyclooctyl)-2-propyn-1-yl]cyanamido}heptanoate. The subsequent steps yield 7-{N-[3-(1-hydroxycyclooctyl)-2-propyn-1-yl]cyanamido}heptanoic acid (B) and 7-{1-[3-(1-hydroxycyclooctyl)-2-propyn-1-yl]ureido}heptanoic acid (C).

Provenance & Evidence