Tetrahydrofuran → HCID 21498439, compound

Participants

Reaction Steps

To a solution of 8.4 g. of 2-methylamino-1,3,4-thiadiazole-5-sulfonyl chloride (see Preparation 1) in 100 ml. of tetrahydrofuran, cooled to about 0° C., there was added dropwise 4.4 g. of methylfurfurylamine. After the addition had been completed, 4.1 g. of triethylamine was added to the mixture dropwise and the mixture was then stirred at ambient room temperature overnight. The reaction product mixture was filtered to remove any salt. The filtrate was concentrated to yield an oil. Water was added to the oil. A precipitate formed which was filtered off and dried. The precipitate weighed about 6.2 g. and had a melting point of about 109°-112° C. It was identified as 2-methylamino-5-[N-methyl-N-furfurylsulfamoyl]-1,3,4-thiadiazole. It was used without further purification in the preparation of some of the final products of the invention.

Provenance & Evidence