N,N'-Dimethylurea → HCID 21498416, compound

Participants

Reaction Steps

To a solution of 3 g. of 2-methylamino-5-[N-methyl-N-furfurylsulfamoyl]-1,3,4-thiadiazole (from Preparation 3) in 50 ml. of toluene was added 1 g. of methyl isocyanate. The reaction mixture was heated at reflux for about 3 hours. The reaction product mixture was cooled and the solid which precipitated was filtered off. The solid weighed about 2.5 g. It was recrystallized from commercial absolute ethanol to give tan crystals weighing about 1 g., and having a melting point of about 131°-132° C. The product was identified by NMR spectrum and elemental analyses as 1-[5-N-furfuryl-N-methylsulfamoyl)-1,3,4-thiadiazol-2-yl]-1,3-dimethylurea.

Provenance & Evidence