HuagongsheHuagongshe Chemistry Print Report · For research reference only
Androstenedione → Dihydrotestosterone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Androstenedione | HCID 6128 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Catalyst | tungsten carbide (WC) | HCID 25504 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Dihydrotestosterone | HCID 10635 | — |
Reaction Steps
0.50 g. of androst-4-ene-3,17-dione is dissolved in 10 ml. of tetrahydrofuran and electrolyzed in 100 ml. of methylamine with 0.5 g. of lithium chloride for 1 hour between a platinum cathode and a tungsten carbide anode at 0.5 A. After the reaction mixture has been worked up and recrystallized, 0.38 g. of 5α-androstan-17β-ol-3-one is obtained, m.p. 172.5° - 173.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03990956 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-76bc9c68416e46bd9f72c9b1f7bbf465 |
| Source note | uspto-grants-1976_11 |