HCID 178467001, compound → HCID 178435013, compound

Participants

Reaction Steps

A mixture of 0.578 g. (1.8 mmol.) of 2-acetyl-3-(2-tetrahydropyranyloxymethyl)quinoxaline 1,4-dioxide and 5.7 ml. of 40% aqueous acetic acid (prepared by mixing 40 parts of glacial acetic acid and 60 parts of water) was maintained at 40° C. for 3 hours. The solvents were removed by evaporation in vacuo. To the residue was added a small quantity of ethyl acetate, which was then removed by evaporation in vacuo. This procedure of adding ethyl acetate and then removing it by evaporation in vacuo was repeated several times. The residue was then washed with methyl isobutyl ketone, which finally afforded 0.354 g. (84% yield) of 1-hydroxy-1-methyl-1,3-dihydrofuro[3,4-b]quinoxaline 4,9-dioxide, m.p. 160°-162° C. (dec.).

Provenance & Evidence