Methyl iodide → HCID 131710522, compound

Participants

Reaction Steps

A stirred suspension of 0.017 m of NaH (washed with petroleum ether) in 50 ml of dimethyl formamide was treated in portions with 5 g (0.0137 m) of 1,2,3,4-tetrahydro-8,9-dimethoxy-3-benzoyl-benzo[c][2,7]naphthyridin-5(6H)-one. After stirring for 10 min, the reaction was treated with 5 g (0.035 m) of CH3I and stirred an additional 45 min. Dilution with water to 250 ml and filtration gave 4.8 g (93%) of crude material. Crystallization from methanol/CH2Cl2 afforded pure material, mp 241°-243° C.

Provenance & Evidence