Methyl isothiocyanate → 8-Methylthiocarbamoylamino-2-phenyl-5,6,7,8-tetrahydroquinoline

HRID 1730015Notes

Reaction equation

[NH2:1][CH:2]1[C:11]2[N:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:8]=[CH:7][C:6]=2[CH2:5][CH2:4][CH2:3]1.[CH3:18][N:19]=[C:20]=[S:21]>>[CH3:18][NH:19][C:20]([NH:1][CH:2]1[C:11]2[N:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:8]=[CH:7][C:6]=2[CH2:5][CH2:4][CH2:3]1)=[S:21]

Participants

Reactant 2

HCID 11167Methyl isothiocyanate

HCID 227087758-Amino-2-phenyl-5,6,7,8-tetrahydroquinoline

Product 1

HCID 214117168-Methylthiocarbamoylamino-2-phenyl-5,6,7,8-tetrahydroquinoline

Procedure

The 8-amino-compound of Example 23 may be treated with methylisothiocyanate to give the title compound following the procedure of Example 4.

Sources & evidence

ORD record: ord-c066c457f4f34c6d9621a65515d284d5
Source dataset: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03991065

Reaction notes

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