Diethylamine → HCID 54478896, compound

Participants

Reaction Steps

5-Ethoxycarbonyl-3-p-methoxystyryl-1,2,4-oxadiazole (1.25 g.) was suspended in dry methanol (5 ml.) and diethylamine (7.25 ml.) was added. The mixture was heated under reflux for 1 hour, when a solution was obtained. The solvent was removed under reduced pressure and the residual oil was dissolved in methanol and treated with charcoal. Evaporation of the filtrate left an oil, which was recrystallised from aqueous methanol to give the amide (1.199 g., 87.4%), m.p. 69°-70°, λmax. (EtOH) 225.5 300 (infl.) and 308 nm. (ε15400, 24400 and 25000), εmax. (CHBr3) 820 (C6H4), 970 (trans-CH=CH), 1650 (CO.N<),

Provenance & Evidence