HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Ethnor
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate sulfate | HCID 3084993 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethnor | HCID 36339 | — |
Reaction Steps
A solution of 47.5 parts of (-)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate sulfate in 500 parts of water is alkalized with 14 parts of a sodium hydroxide solution 50%. The product is extracted twice with 325 parts of dichloromethane. The combined extracts are dried, filtered and evaporated in vacuo. The residue is crystallized from 2,2'-oxybispropane, yielding (-)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03991072 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-5bdca24f7ac64c88b979240b23bff893 |
| Source note | uspto-grants-1976_11 |