Hydrochloric Acid → HCID 21498908, compound

Participants

Reaction Steps

A solution of 3.09 g (0.012 mole) of 3-(4-methoxyphenacyl)-2,3,5,6-tetrahydrothiopyran-4-one, 1.22 g of dimethylaminopropylamine, 20 ml. of ethanol and one drop of concentrated hydrochloric acid is heated under reflux for 1.5 hours, cooled to ambient temperature, treated with 4 ml. of saturated ethereal hydrogen chloride, and diluted to the cloud point with ether. A brown solid precipitates. The solid is recrystallized from 2-propanol to give tan crystals of 1-(3-dimethylaminopropyl)-2-(4-methoxyphenyl)-1,4,6,7-tetrahydrothiopyrano[4,3-b]pyrrole hydrochloride, m.p. 193 to 194°C.

Provenance & Evidence