HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → 4-{[(Propan-2-yl)amino]methylidene}-1-benzoxepine-3,5(2H,4H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(Bromoacetyl)-4H-1-benzopyran-4-one | HCID 21486404 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-{[(Propan-2-yl)amino]methylidene}-1-benzoxepine-3,5(2H,4H)-dione | HCID 54243557 | 68% |
Reaction Steps
A mixture of 8.0g (0.03 mole) of 3-(bromoacetyl)chromone, 3.78g (0.064 mole) of isopropylamine, 200ml of methylene chloride and 30g of powdered anhydrous potassium carbonate was stirred at room temperature for 4 hours. The solids were filtered and the dark filtrate was filtered through layer of silica gel. This filtrate was concentrated to dryness. Recrystallization from ether gave 5.0g (68%) of product; m.p. 89°-91°. Recrystallization from isopropyl ether gave pure product; m.p. 92°-93°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03991082 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-b62c101384dd400ca5a1e8d0b10764c9 |
| Source note | uspto-grants-1976_11 |