6-(Hydroxymethyl)-1,3,3-trimethylbicyclo[2.2.2]octa-5,7-dien-2-one → HCID 21499159, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 30 g of 1,3,3-trimethyl-6-hydroxymethyl-bicyclo-(2.2.2)-octa-5,7-dien-2-one, 0.5 g of 5% of palladium-carbon and 300 ml of isopropyl alcohol is added to a stirred autoclave. The autoclave is pressurized to 400 pounds per square inch with hydrogen and heated to 100° C for 6 hours. At the end of this time, the mixture is filtered, stripped of solvent and vacuum distilled, yielding about 27 g (90%) of the product, 1,3,3-trimethyl-6-hydroxymethyl-bicyclo-(2.2.2)-octan-2-one, having the structure: ##SPC41##

Provenance & Evidence