Diethyl Ether → HCID 54424208, compound

Participants

Reaction Steps

A mixture of 30 g of triphenylphosphine, 200 ml of anhydrous ether and 11 g of methylene chloride is cooled to -30° and 77 ml of 1.3M n-butyl lithium solution is added over one hour. To the stirred solution is added 11 g of crude 1,3,3-trimethyl-bicyclo-(2.2.2)-octan-2-one-6-carboxaldehyde. The mixture is slowly heated to reflux and held at reflux for 2 hours. The mixture is poured into 100 ml of water and the organic layer is separated and dried over Mg 804 and the solvent is stripped off the product. Structure: ##SPC43##

Provenance & Evidence