3-(Trifluoromethyl)phenol → HCID 21401583, compound

HRID 1730135Notes

Reaction equation

HRID 1730135 reaction equation
FC1C=CC(O)=CC=1.FC(F)(F)C1C=C(O)C=CC=1.[OH:20][CH:21]([CH2:41][O:42][C:43]1[CH:48]=[CH:47][CH:46]=[C:45]([C:49]([F:52])([F:51])[F:50])[CH:44]=1)[CH2:22][CH2:23][CH2:24][N:25]([CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][C:36]([O:38]CC)=[O:37])[S:26]([CH3:29])(=[O:28])=[O:27]>>[OH:20][CH:21]([CH2:41][O:42][C:43]1[CH:48]=[CH:47][CH:46]=[C:45]([C:49]([F:52])([F:50])[F:51])[CH:44]=1)[CH2:22][CH2:23][CH2:24][N:25]([CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][C:36]([OH:38])=[O:37])[S:26]([CH3:29])(=[O:28])=[O:27]

Participants

4

Reactant 3

HCID 73763-(Trifluoromethyl)phenolHCID 97324-FluorophenolHCID 21401591HCID 21401591, compound

Product 1

HCID 21401583HCID 21401583, compound

Procedure

The synthesis of this compound is carried out as described in Example 1 except that, in Step D, the p-fluorophenol is replaced by an equimolar amount of 3-trifluoromethylphenol. The product of Step D is thus ethyl 7-{N-[4-hydroxy-5-(3-trifluoromethylphenoxy)pentyl]-methanesulfonamido}heptanoate. The subsequent hydrolysis step yields 7-{N-[4-hydroxy-5-(3-trifluoromethylphenoxy)-pentyl]-methanesulfonamido}heptanoic acid (E).

Workup

  1. customThe synthesis of this compound
  2. customThe subsequent hydrolysis step

Sources & evidence

ORD record
ord-715fb1e25a0549578a528a9e5c257ad1
Source dataset
uspto-grants-1976_11
Patent number
US03991106

Reaction notes

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