4-Fluorophenol → HCID 21401603, compound

HRID 1730136Notes

Reaction equation

HRID 1730136 reaction equation
FC1C=CC(O)=CC=1.FC1C=CC(S)=CC=1.[OH:17][CH:18]([CH2:38][S:39][C:40]1[CH:45]=[CH:44][C:43]([F:46])=[CH:42][CH:41]=1)[CH2:19][CH2:20][CH2:21][N:22]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C:33]([O:35]CC)=[O:34])[S:23]([CH3:26])(=[O:25])=[O:24]>>[OH:17][CH:18]([CH2:38][S:39][C:40]1[CH:45]=[CH:44][C:43]([F:46])=[CH:42][CH:41]=1)[CH2:19][CH2:20][CH2:21][N:22]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C:33]([OH:35])=[O:34])[S:23]([CH3:26])(=[O:24])=[O:25]

Participants

4

Reactant 3

HCID 97324-FluorophenolHCID 677894-FluorothiophenolHCID 21401619HCID 21401619, compound

Product 1

HCID 21401603HCID 21401603, compound

Procedure

The synthesis of this compound is carried out as described in Example 1 except that, in Step D, the p-fluorophenol is replaced by an equimolar amount of 4-fluorothiophenol. The product of Step D is thus ethyl 7-{N-[4-hydroxy-5-(4-fluorophenylthio)pentyl]methanesulfonamido}-heptanoate.

Workup

  1. customThe synthesis of this compound

Sources & evidence

ORD record
ord-2b7cfaf4b9df4d97ae5e4ffaa9829967
Source dataset
uspto-grants-1976_11
Patent number
US03991106

Reaction notes

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