反应详情

温度

110 °C

A 250 ml. three necked flask was fitted with a mechanical stirrer and a reflux condenser with drying tube. The flask is charged with 50 ml. of acetic anhydride and 3.85 g of 2-amino-4,6-dichloropyrimidine (0.025 mole). Then, 10 ml. of acetyl chloride was added slowly and the mixture was heated to 110° C for 8 hours. The mixture was allowed to stand overnight at room temperature. The crystalline solid product which formed was filtered and washed with water and sodium bicarbonate solution. It was then recrystallized from 50% alcohol. There was obtained 3.8 g of 2-acetamido-4,6-dichloropyrimidine (PY-25) in the form of white crystals, melting point, 198°-200° C, yield, 74.5%.

1. customthree necked flask was fitted with a mechanical stirrer and a reflux condenser
2. customwith drying tube
3. additionThe flask is charged with 50 ml
4. customThe crystalline solid product which formed
5. filtrationwas filtered
6. washwashed with water and sodium bicarbonate solution
7. customIt was then recrystallized from 50% alcohol