Pyridine → Diisopropyl Ether

Participants

Reaction Steps

To a stirred solution of 48.2 parts of 2,3-bis(2,4-dichlorophenyl)-1-propanol in 150 parts of pyridine are added dropwise 14 parts of mesyl chloride at room temperature. Upon completion, stirring at room temperature is continued overnight. The reaction mixture is poured onto water and the product is extracted twice with diisopropylether. The combined extracts are washed successively three times with a dilute hydrochloride acid solution and once with water, dried, filtered and evaporated. The residue is crystallized first from methanol and then from diisopropylether, yielding 25.8 parts of 2,3-bis(2,4-dichlorophenyl)-1-propanol methanesulfonate; mp. 84° C.

Provenance & Evidence