Acetic Acid → HCID 21390821, compound

HRID 1730186Notes

Reaction equation

HRID 1730186 reaction equation
[NH2:1][N:2]1[NH:6][CH:5]=[C:4]([C:7]2[N:8]([CH2:15][CH2:16][OH:17])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=2)[S:3]1.S(=O)(=O)(O)O.[C:23](O)(=[O:25])[CH3:24]>>[NH2:1][N:2]1[NH:6][CH:5]=[C:4]([C:7]2[N:8]([CH2:15][CH2:16][O:17][C:23](=[O:25])[CH3:24])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=2)[S:3]1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 21390811HCID 21390811, compound

Product 1

HCID 21390821HCID 21390821, compound

Procedure

The sample (0.1 g.) of 2-amino-5-[1-(2-hydroxyethyl)-5-nitro-2-imidazolyl]thiadiazole is dissolved in 2 ml. of hot glacial acetic acid and a drop of concentrated sulfuric acid is added. The solution is refluxed for 45 minutes, cooled and poured on ice to give a yellow solid. This solid is collected, washed with water and dried; the yield is 0.1 g., melting point 159°-162° C. (turbid). A purified sample of the 2-amino-5-[1-(2-acetoxyethyl)-5-nitro-2-imidazolyl]thiadiazole, melts at 164°- 165.5° C.

Workup

  1. temperatureThe solution is refluxed for 45 minutes
  2. temperaturecooled
  3. additionpoured on ice
  4. customto give a yellow solid
  5. customThis solid is collected
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-8a4e65b574d3403eb8f2f0898d615e56
Source dataset
uspto-grants-1976_11
Patent number
US03991200

Reaction notes

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