HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 2-(2-Hydroxymethylamino-5-thiadiazolyl)-1-methyl-5-nitroimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 2-(2-Amino-5-thiadiazolyl)-1-methyl-5-nitroimidazole | HCID 21390816 | — |
| Product | 2-(2-Hydroxymethylamino-5-thiadiazolyl)-1-methyl-5-nitroimidazole | HCID 21390852 | — |
Reaction Steps
A suspension of 5 g. of 2-(2-amino-5-thiadiazolyl)-1-methyl-5-nitroimidazole in 200 ml. of 36% aqueous formaldehyde solution is stirred for 20 hours at room temperature. The suspension is cooled in ice, and the insoluble solid is collected by filtration and washed with acetone. The yield of the title compound is 6.15 g., melting point 177° C. with decomposition (rapid heating).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03991200 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-67813a1191204ffe860433e1776c1bfe |
| Source note | uspto-grants-1976_11 |