HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 2-[2-(4-Methyl-1-piperazinyl)-5-thiadiazolyl)-1-methyl-5-nitroimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 2-(2-Piperidino-5-thiadiazolyl)-1-methyl-5-nitroimidazole | HCID 21390837 | — |
| Product | 2-[2-(4-Methyl-1-piperazinyl)-5-thiadiazolyl)-1-methyl-5-nitroimidazole | HCID 21390838 | — |
Reaction Steps
The preparation of the above compound is carried out in the manner described for the 2-piperidino derivative (Example 28), an equivalent of 1-methylpiperazine replacing the piperidine. The crude product is purified by recrystallization from 2-methoxyethanol and melts at 242°-244° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03991200 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-ddc0afdf3c1241b3bf665258ac784fa3 |
| Source note | uspto-grants-1976_11 |