Miconazole → HCID 178478169, compound

Participants

Reaction Steps

4.2 parts of 1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazole, 3.1 parts of 2-(p-bromophenoxy)ethyl bromide and 24 parts of acetonitrile are stirred together overnight at reflux temperature to obtain the desired 1-[2-(p-bromophenoxy)ethyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium bromide product. The product is recovered from the reaction mixture by (a) diluting the latter with diisopropyl ether (b) adding three drops of water to precipitate the product as a crystalline solid, and (c) filtering off the precipitated solid. After purification by recrystallization from a mixture of 4-methyl-2-pentanone and diisopropyl ether, the product has a melting point of 131.5°-132.5° C.

Provenance & Evidence