Maleic Anhydride → HCID 54349870, compound

HRID 1730263Notes

Reaction equation

HRID 1730263 reaction equation
[NH2:1][NH2:2].[Cl:3][C:4]1[CH:21]=[CH:20][C:7]2[O:8][C:9]3[CH:19]=[CH:18][CH:17]=[CH:16][C:10]=3[CH2:11][N:12]([C:13]([OH:15])=O)[C:6]=2[CH:5]=1.[C:22]1(=[O:28])[O:27][C:25](=[O:26])[CH:24]=[CH:23]1>C1C=CC=CC=1.C(Cl)Cl>[C:22]([CH:23]=[CH:24][C:25]([NH:1][NH:2][C:13]([N:12]1[CH2:11][C:10]2[CH:16]=[CH:17][CH:18]=[CH:19][C:9]=2[O:8][C:7]2[CH:20]=[CH:21][C:4]([Cl:3])=[CH:5][C:6]1=2)=[O:15])=[O:26])([OH:27])=[O:28]

Participants

4

Reactant 2

HCID 7923Maleic AnhydrideHCID 68138195HCID 68138195, compound

Product 1

HCID 54349870HCID 54349870, compound

Reagents, catalysts & solvents 1

HCID 23443464Methane, dichloro-, compd. with benzene (1:1)Solvent

Procedure

To 1 part of 8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine-10-carboxylic acid hydrazine dissolved in 50 parts by volume of 1:1 benzene-methylene chloride solution, is added in one portion 0.344 part of maleic anhydride.The reaction mixture is stirred at room temperature for 24 hours, and the solvent is evaporated to yield an oil which is crystallized from benzene-ethyl acetate solution. Recrystallization from ethyl acetate-cyclohexane-ethanol solution yields 1-(3-carboxypropenoyl)-2-(8-chloro-10,11-dihydrodibenz[b,f]-[1,4]oxazepine-10-carbonyl)hydrazine, melting at about 171°- 172°. This compound can be represented by the following structural formula ##SPC2##

Workup

  1. customthe solvent is evaporated
  2. customto yield an oil which
  3. customis crystallized from benzene-ethyl acetate solution
  4. customRecrystallization from ethyl acetate-cyclohexane-ethanol solution

Sources & evidence

ORD record
ord-8829b7e37ad14a118f37bfdcf2fcedf4
Source dataset
uspto-grants-1976_11
Patent number
US03992375

Reaction notes

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