Benzene → HCID 21497024, compound

HRID 1730265Notes

Reaction equation

HRID 1730265 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[O:6][C:7]3[CH:18]=[CH:17][CH:16]=[CH:15][C:8]=3[CH2:9][N:10]([C:11]([NH:13][NH2:14])=[O:12])[C:4]=2[CH:3]=1.C1C=CC=CC=1.[C:27](OC(=O)C)(=[O:29])C.C(O)=O>O>[CH:27]([NH:14][NH:13][C:11]([N:10]1[CH2:9][C:8]2[CH:15]=[CH:16][CH:17]=[CH:18][C:7]=2[O:6][C:5]2[CH:19]=[CH:20][C:2]([Cl:1])=[CH:3][C:4]1=2)=[O:12])=[O:29]

Participants

6

Reactant 4

HCID 241BenzeneHCID 284Formic AcidHCID 7918Acetic Anhydride2×HCID 135604618-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide

Product 1

HCID 21497024HCID 21497024, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of 2.88 parts of 8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine-10-carboxylic acid hydrazide with 100 parts by volume of dry benzene is added about 1 part offormic acetic anhydride, prepared from 10.2 parts of acetic anhydride and 4.6 parts of formic acid. The reaction mixture is stirred until no evidence of starting material is detected, at which time 100 parts of water is added with vigorous stirring. Stirring is continued for about 1 hour, at the end of which time the mixture is filtered and the resulting product is dried to afford 1-formyl-2-(8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine-10-carbonyl)hydrazine, melting at about 177°-181°.

Workup

  1. additionis added with vigorous stirring
  2. stirringStirring
  3. filtrationthe mixture is filtered
  4. customthe resulting product is dried

Sources & evidence

ORD record
ord-a2cfc9dbc84c46609c95ee6362eda757
Source dataset
uspto-grants-1976_11
Patent number
US03992375

Reaction notes

Loading…