Dimethylformamide → HCID 178479697, compound

Participants

Reaction Steps

4-Hydroxy-1,5-naphthyridine-3-carboxylic acid was added to a mixture of 0.73 g of dimethylformamide and 1.56 g of thionyl chloride in benzene withstirring, and stirring was continued at 40° - 85° C for 3 hours. The precipitated crystals were collected by filtration, washed withbenzene and dried under reduced pressure to give 2.37 g of 4-hydroxy-1,5-naphthyridine-3-carbonyl chloride hydrochloride. Purity (determined by NMR analysis after esterification), 96.3 %.

Provenance & Evidence