Sulfuric Acid → HCID 21487149, compound

Participants

Reaction Steps

A solution of 15 g. (37 mmol) of [[7-bromo-5-(2-pyridyl)-3H-1,4-benzodiazepine-2-yl]amino]acetaldehyde dimethyl-acetal in 50 ml. of concentrated sulfuric acid is allowed to stirat room temperature under nitrogen overnight, poured onto crushed ice and neutralized with an aqueous sodium hydroxide solution. The product is extracted with chloroform and the chloroform washed with brine, dried oversodium sulfate and concentrated to an oil in vacuo. On trituration, 10.2 g.(81%) of 8-bromo-6-(2-pyridyl)-4H-imidazo[1,2-a][1,4]benzodiazepine, a yellow crystalline product of melting point 208°-210°, is obtained.

Provenance & Evidence