Phenylacetyl chloride → HCID 131710523, compound

Participants

Reaction Steps

For example, p-nitrobenzyl 7-amino-3-methylthio-3-cephem-4-carboxylate is reacted with phenylacetyl chloride in cold aqueous acetone containing an excess of sodium bicarbonate to provide the acylated compound p-nitrobenzyl 7-phenylacetamido-3-methylthio-3-cephem-4-carboxylate. Similarly, diphenylmethyl 7-amino-3-(1-methyl-1H-tetrazole-5-ylthio)-3-cephem-4-carboxylate is reacted with 2-thienylacetyl chloride in aqueous acetone at a temperature of about 5° to about 10° C. in the presence of sodium bicarbonate to provide the 7-[2-(2-thienyl)acetamido]ester.

Provenance & Evidence