5-(2-Chloroethyl)-1,2,3-trimethoxybenzene → 1-[2-(3,4,5-Trimethoxyphenyl)ethyl]-4-benzamidopiperidine

HRID 1730329Notes

Reaction equation

HRID 1730329 reaction equation
C1(CC[N:9]2[CH2:14][CH2:13][CH:12]([NH:15][C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:11][CH2:10]2)CCCCC1.[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH:32]=[C:33]([O:37][CH3:38])[C:34]=1[O:35][CH3:36])[CH2:29][CH2:30]Cl>O>[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH2:29][CH2:30][N:9]2[CH2:14][CH2:13][CH:12]([NH:15][C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:11][CH2:10]2)[CH:32]=[C:33]([O:37][CH3:38])[C:34]=1[O:35][CH3:36]

Participants

4

Reactant 2

HCID 138633315-(2-Chloroethyl)-1,2,3-trimethoxybenzeneHCID 214132691-[2-(Cyclohexyl)ethyl]-4-benzamidopiperidine

Product 1

HCID 214132581-[2-(3,4,5-Trimethoxyphenyl)ethyl]-4-benzamidopiperidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared in exactly the same way as for the compound of Example 1 except that 3,4,5-trimethoxyphenethyl chloride was used in place of cyclohexylethyl bromide. The title compound was obtained as a monohydrate (1.2 g.), m.p. 193°-4° C. (Found: C, 66.7; H, 7.6; N, 6.9. C20H30N2O4. H2O requires C, 66.4; H, 7.5; N, 6.7%).

Sources & evidence

ORD record
ord-39b64e37972c44f89f644fcff2a5d9fd
Source dataset
uspto-grants-1976_11
Patent number
US03992389

Reaction notes

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